Matrix Science Pharma (MSP)

Biosynthesis of Iron Oxide Nanoparticles Using Ethyl Acetate Extract of Chaetomium cupreum and their Anticancer Activity

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February 13, 2026 In Uncategorized

msp.02.2020.23.30

BIOSYNTHESIS OF IRON OXIDE NANOPARTICLES USING ETHYL ACETATE EXTRACT OF CHAETOMIUM CUPREUM AND THEIR ANTICANCER ACTIVITY

Journal: Matrix Science Pharma (MSP)
Author: Nazir Ahmad Wani, Waseem Iqbal Khanday, Sharmila Tirumale

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_6_20

ABSTRACT

Objectives: The synthesis of iron oxide NP and their anticancer potential was investigated. Methods: The anticancer activities of biosynthesized iron oxide NP were evaluated using tetrazolium bromide assay, measurement of reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and inhibition of tumorsphere formation. Results: In the present study, the X‑ray diffraction shows the presence of gamma phase iron oxide NP withe the type of Fe2 O3. The anticancer potential of iron oxide NP was investigated against human breast cancer cell line. The anticancer activity of biosynthesized iron oxide NP against MCF‑7 was 20.5, 30.5, 41.1, 55.3 67.5, and 75.25 at 50 µg/ml after 1, 5, 10, 15, 20, and 24 h of treatment, respectively. The results showed that Fe2 O3 NP induced ROS generation to 68.22% at the concentration of 25 µg/ml and 83.66% at 50 µg/ml as compared to 48.22 in control after 15 h of treatment. The results showed that Fe2 O3 NP treatment increased depolarization MMP to 8.52% at 25 µg/ml and 10.74% at 50 µg/ml as compared to 6.35% in untreated cells after 24 h. Thus, treatment with Fe2 O3 NPs showed significant inhibition of MCF‑7 tumorsphere formation at higher concentration. Conclusions: The biosynthesized iron oxide NP using ethyl acetate extract of C. cupreum exhibit significant anticancer activity

Pages 23-30
Year 2020
Issue 2
Volume 4

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February 13, 2026 In Uncategorized

msp.01.2020.18.22

HIGHLIGHTING THE NUTRITIONAL AND MEDICINAL VALUE OF ASPARAGUS ALONG WITH ITS CULTIVATION PRACTICES

Journal: Matrix Science Pharma (MSP)
Author: Sandesh Thapa, Sara Rawal, Sarika Bist

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_4_20

ABSTRACT

Objectives: A study shows that Asparagus was not any new plant to Nepalese, it grew well in the subtropical vegetation of the hilly and Terai regions of our country through its length and breadth naturally, but its importance was still undervalued. Methods: Comprising about 300 species including both wild and edible species, Asparagus is a plant of marine habitats owing a very modified shoot system that primarily adapts itself for various purposes of a plant to survive such as climbing, protection, adaptation in arid habitat, and many more. Furthermore, the review dealt with the cultivation practices which, in turn, highlighted the virtue of its methods that should be included for getting Asparagus more and more economically excellent. Results: Study and data accounted acknowledged that Asparagus farming is not getting the kind of attention, techniques, and interest of people that it needs to get. Conclusions: The antifungal susceptibility by disc‑diffusion test found that the inhibition growth on F. verticillioides by the aqueous extract occurred at a concentration of 100 mg/mL with an average diameter of 7.3 mm ± 0.06. C. albicans, A. niger, and M. gypseum were shown to be insusceptible to both the extracts.

Pages 18-22
Year 2020
Issue 1
Volume 4

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February 13, 2026 In Uncategorized

msp.01.2020.13.17

ANTI‑FUNGAL STUDY ON AQUEOUS AND ETHANOLIC LEAVES EXTRACTS OF PIPER SARMENTOSUM

Journal: Matrix Science Pharma (MSP)
Author: Maizatul Akma Ibrahim, Aiesyaa Majdiena Emlee

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_3_20

ABSTRACT

Objectives: Previous studies provided evidence for its therapeutic properties such as antimicrobials, anticholesterolemic, and antioxidant. An antifungal agent is highly important to cure diseases caused by pathogenic fungi. Methods: Thus, the aim of this study is to discover the antifungals activity of P. sarmentosum leaves’ aqueous and ethanolic extracts against four pathogenic fungi, namely Candida albicans, Aspergillus niger, Fusarium verticillioides, and Microsporum gypseum. Results: The yield percentage of the aqueous extract was 17.72%, followed by ethanolic extract with 11.95% of yield. Phytochemical analysis by gas chromatography–mass spectrometer showed the presence of acetic acid, hydrocinnamic acid, oxazole, guanidine, pyranone, benzofuran, β‑asarone, and 1‑pentadecene in aqueous extracts, while it showed the presence of β‑asarone, α‑asarone, myristicin, apiol, isocaryophyllene, 1,1‑dichlorocyclopentane, and 14‑chloro‑1‑tetradecanol in ethanolic extract. Conclusions: The antifungal susceptibility by disc‑diffusion test found that the inhibition growth on F. verticillioides by the aqueous extract occurred at a concentration of 100 mg/mL with an average diameter of 7.3 mm ± 0.06. C. albicans, A. niger, and M. gypseum were shown to be insusceptible to both the extracts.

Pages 13-17
Year 2020
Issue 1
Volume 4

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February 13, 2026 In Uncategorized

msp.01.2020.09.12

SYSTEMATIC SIGNIFICANCE OF THE FOLIAR TRICHOMES IN SELECTED MELASTOMA L. SPECIES FROM FRASER HILL, PAHANG

Journal: Matrix Science Pharma (MSP)
Author: Z. Siti‑Maisarah, Che Nurul Aini Che Amri, S. Rozilawati, M. Y. Noor‑Syaheera

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_2_20

ABSTRACT

Objectives: This study aims to investigate the systematic significance of foliar trichomes in the identification and classification of Melastoma species. Methods: Methods of investigation involved cross‑section using sliding microtomes on petiole and midrib, epidermal peel, and leaf clearing and observation under a light microscope. Results: The investigation showed that the genus of Melastoma seems to have a great variation of foliar trichomes. This present study has reported nonglandular trichomes in all species studied. However, six types of trichomes were discovered which serve as distinct variations of taxonomic values, such as simple multiseriate (short, pointed end), simple multiseriate (long, pointed end), simple multiseriate (short, hooked end), simple multiseriate (long, hooked end), strigose–setose, and scales trichomes. Surprisingly, the presence of simple multiseriate (long, hooked end) trichome only in M. muticum could be a criterion to diagnose the species. Conclusions: In conclusion, the present study revealed that the foliar trichomes possess as systematic significance in the identification and classification of Melastoma either at genus or species level.

Pages 09-12
Year 2020
Issue 1
Volume 4

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February 13, 2026 In Uncategorized

msp.01.2020.04.08

ASSESSMENT OF COMMUNITY PHARMACIST’S KNOWLEDGE AND SKILLS ABOUT APPROPRIATE INHALER TECHNIQUE DEMONSTRATION IN KHARTOUM LOCALITY: A CROSS‑SECTIONAL STUDY

Journal: Matrix Science Pharma (MSP)
Author: Arwa Husham Omer, Bashir Alsiddig Yousef

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_1_20

ABSTRACT

Objectives: Inhalation represents the best choice of administration for the delivery of drugs to treat respiratory disorders such as asthma. Thus, the correct inhaler technique is required to ensure optimal clinical outcomes and improve the quality of life. Community pharmacists are responsible for counseling patients and their knowledge and skills of inhalers. This study aimed to assess the knowledge and skills of community pharmacists in demonstrating different inhalation device techniques in Khartoum locality. Methods: This was a cross‑sectional observational study concerning Khartoum locality pharmacies using a mystery patient method. The data were collected using a checklist for each device, which was filled by the investigator after visiting the pharmacy, and then the data were analyzed descriptively using Statistical Package for the Social Sciences. Results: The study covered 232 pharmacies. Most of the pharmacists get the score of an adequate level of knowledge and skills; the percentage levels for each device were as 58.2%, 65.7%, and 58.8% for pressurized metered‑dose inhaler (Ventolin®), dry powder inhaler (Turbuhaler™, Symbicort®), and dry powder inhaler (Diskus™, Seretide®), respectively. However, some of the pharmacists get the score of “don’t know.” Although most pharmacists achieve an adequate score, they were varying in percentage when demonstrating critical steps for each device. Conclusions: The community pharmacists who are expected to educate asthmatic patients on how to deal with their inhaler’s devices scored an adequate level of knowledge and skill on demonstrating different inhaler’s device, so an extra effort should be made to level them up in that area through regular training programs.

Pages 04-08
Year 2020
Issue 1
Volume 4

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February 13, 2026 In Uncategorized

msp.01.2020.01.03

RESEARCH ON THE ROLE OF TOLL‑LIKE RECEPTOR 2 AND TOLL‑LIKE RECEPTOR 4 AND ITS SIGNAL PATHWAY IN THE PATHOGENESIS OF PRIMARY GOUT ARTHRITIS

Journal: Matrix Science Pharma (MSP)
Author: R. J. Cui, M. Li, G. Tuerxun, Y. Li, S. S. Xie

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_5_19

ABSTRACT

Objectives: The study objective was to research the role of toll‑like receptor (TLR) 2 and TLR 4 and its signal pathway in the pathogenesis of primary gout arthritis. Methods: Seventy‑two patients with primary gout arthritis were selected as the experimental group and 72 healthy controls were selected as the control group. The real‑time fluorescence quantitative polymerase chain reaction method was used for testing. Blood uric acid (UA) level, interleukin (IL) IL‑1β level, and TLR4 and TLR2 were observed in the two groups. Results: Compared with the control group, the levels of UA, IL‑1β, and TLR4 in the observation group were significantly higher than those in the control group, and there was a statistically significant difference between the two groups (P < 0.05). There was no positive correlation between plasma UA level, IL‑1β level, and TLR2 (P > 0.05). There was no correlation between TLR2 and serum UA level and IL‑1β level in the control group (P > 0.05). Conclusions: TLR4 and IL‑1β signaling acceleration is closely related to gouty arthritis. When the TLR4 signal pathway is activated, the UA salt crystal changes in the patient’s body.

Pages 01-03
Year 2020
Issue 1
Volume 4

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February 13, 2026 In Uncategorized

msp.02.2019.43.46

MUTAGENESIS OF CELLULOSE SYNTHASE (CESA‑LIKE) GENE IN TOMATO USING CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT/CAS9‑SYSTEM

Journal: Matrix Science Pharma (MSP)
Author: Nurul Hidayah Samsulrizal

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_11_19

ABSTRACT

Objectives: To better understand the relationship between cell wall remodelling and fruit softening, an understanding of cell wall structure is necessary. Methods: Cellulose synthase gene that consists of cellulose synthase (CesA-like) plays important role in cellulose biosynthesis. However, CesA family genes are yet to be fully characterized in Solanaceae species. Results: In this study, we generated transgenic plants to test the role of CesA like gene in texture changes using tomato (Solanum lycopersicum) as a model system. We used the recently developed clustered regularly interspaced short palindromic repeat/Cas9 DNA editing technology to generate mutations in the target gene. Conclusions: Nevertheless, there was no mutation recovered in the CesA-like gene, and this indicates that this gene product is likely essential for regeneration of plantlets from tissue culture.

Pages 43-46
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.40.42

STUDY ON THE EFFECT OF MUSIC THERAPY ON PSYCHOLOGICAL INTERVENTION OF PATIENTS AFTER OPERATION

Journal: Matrix Science Pharma (MSP)
Author: Y. Zhang, L. L. Sun

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_7_19

ABSTRACT

Objectives: The objective was to explore the effect of music therapy on psychological intervention of patients after operation. Methods: The patients were divided into observation group and control group with an average of 68 patients after the outpatient operation. Routine psychological nursing was administered to the patients after operation in the control group and patients in the observation group were administered music therapy on the basis of routine psychological nursing. The psychological anxiety value of the two groups of patients was assessed by Zung Self‑Rating Anxiety Scale. At the same time, the blood pressure, pulse, and pain of the two groups of patients were compared. Results: The blood pressure, pulse, and pain degree of the patients in the observation group were better than those in the control group. The psychological anxiety value of the two groups was statistically significantly better than that of the control group (P < 0.05). Conclusions: Music therapy has an important influence on the psychological intervention of postoperative patients. Patients’ psychological anxiety can be reduced by the use of music therapy at the same time will reduce the psychological anxiety of the patients, improve the psychological status of the patients, help the patients to maintain the stability of vital signs and help the patients recover after operation.

Pages 40-42
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.37.39

STUDY ON THE DIFFERENCE OF WEIGHT REDUCTION EFFECT BETWEEN HIGH‑INTENSITY INTERVAL TRAINING AND PERSISTENT AEROBIC EXERCISE FOR FEMALE COLLEGE STUDENTS

Journal: Matrix Science Pharma (MSP)
Author: Y. Zhang, L. L. Sun

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_6_19

ABSTRACT

Objectives: The aim was to study the effect of persistent aerobic exercise and high‑intensity interval training (HIIT) on weight loss of female students. Methods: Seventy‑two college students were selected as the research subjects, and they were randomly divided into the control group and the observation group. Thirty‑six cases in the control group were doing the persistent aerobic exercise and 36 in the observation group were using the HIIT weight loss method. The waist‑to‑hip ratio, body weight, and body fat were observed and recorded in two groups. Results: The waist‑to‑hip ratio of female students in the control group was significantly lower than that in the observation group, and the difference between the two groups was statistically significant (P < 0.05). The weight loss rate of female college students in the observation group was significantly higher than that in the control group, and the difference between the two groups was statistically significant (P < 0.05). The changes in body fat in female college students in the control group were significantly greater than those in the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusions: Compared with the continuous aerobic exercise method, the HIIT weight‑loss method has a more significant effect on female college students’ weight loss and has a certain safety

Pages 37-39
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.31.36

ASSESSMENT OF NUTRITIONAL STATUS OF UNDER 5‑YEAR‑OLD CHILDREN IN BANADIR HOSPITAL, MOGADISHU, SOMALIA

Journal: Matrix Science Pharma (MSP)
Author: Abdikadir Ahmed Omar, Nadira Mehriban

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_12_19

ABSTRACT

Objectives: Nutritional status of children is a proxy indicator for assessing the entire population health status and one of the major predictors of child survival. Despite the various efforts, malnutrition among children is remaining as a major public health problem in Somalia. The study objective was to assess the nutritional status of under 5‑year‑old children in Banadir Hospital, Mogadishu, Somalia. Methods: A descriptive cross‑sectional study was conducted among 150 under‑five children. Sociodemographic characteristic, usual dietary intake and assess adequacy, breastfeeding and complementary feeding pattern of the mothers, and anthropometric index of the children were collected by using semi‑structured questionnaire. Results: Age categorized into 0–1 years old were 52.7%, 32.0% were 1–2 years old, 8.7% were 3–4 years old, and 6.7% were 4–5 years old. With mean and standard deviation of 17.44 ± 13.096, the age was the most critical variable because it was one of the scales of the Mental Adjustment to Cancer (MAC) measurements and target objective of the study. MAC test showed that 49.3% of the children were severe, 16.0% of the children were mild malnourished, and 34.7% of the children were well‑nourished children. Based on height‑for‑age chronic malnutrition, 16.0% of the respondents were severe, 14.7% of the respondents were moderate, 24.0% of the respondents were mild, and 45.3% of the respondents were normal. According to the weight‑for‑height acute malnutrition, 30.7% of the respondents were severe, 19.3% of the respondents were moderate, 10.7% of the respondents were mild, and 39.3% of the respondents were normal. Conclusions: The findings showed that the nutritional status of under‑five children was quite poor. Also from the results, it is evident that malnutrition is still a major public health problem among young children due to the poor socioeconomic status (poverty and poor educational background) of their parents, and thus, there is a need for better nutrition of the Somali child.

Pages 31-36
Year 2019
Issue 2
Volume 3

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