Matrix Science Pharma (MSP)

Clinical Profiling of Polycystic Ovary Syndrome Patients in Kashmir Population

February 19, 2026 In Uncategorized

msp.01.2022.23.34

CLINICAL PROFILING OF POLYCYSTIC OVARY SYNDROME PATIENTS IN KASHMIR POPULATION

Journal: Matrix Science Pharma (MSP)
Ahila Ashraf, Rajesh Singh, Shahnawaz Mir

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_4_22

ABSTRACT

Polycystic ovary syndrome (PCOS) is a widespread premenopausal hereditary disease of reproductive women with endocrinopathy and metabolic disorders. The characteristic features of PCOS include excess androgens, hirsutism, irregular menses, polycystic ovaries, and follicular failure making the women unproductive. PCOS is heterogeneous disorder, lacking the knowledge of definite mechanism of pathogenesis. The Rotterdam diagnostic criteria for defining PCOS include excess androgens, irregular or no ovulation, and polycystic ovaries. However, in the absence of auxiliary specific diagnostic criteria, PCOS is determined by hyperandrogenism and follicular failure.[8] In spite of contentious viewpoints on current criteria for PCOS diagnosis, a professional opinion based on blood testing, an ultrasound, and pelvic examination can corroborate the diagnosis.[

Pages 23-34
Year 2022
Issue 1
Volume 6

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February 19, 2026 In Uncategorized

msp.01.2022.11.22

ETHNOBOTANICAL STUDY OF MEDICINAL PLANTS PRACTICED AT MYAGDI DISTRICT, NEPAL

Journal: Matrix Science Pharma (MSP)
Anit Poudel

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_3_22

ABSTRACT

Medicinal plants have been used from time immemorial to cure human diseases and injuries. They are rich in secondary metabolites and are the principal sources of raw drugs. Over three‑quarters of the world’s population rely mainly on plants and plant extracts for health care. Medicinal plants are used in the diagnosis, prevention, and elimination of physical and mental imbalance. Ayurveda, Naturopathy, Homeopathy, Unani, Amchi, and Acupuncture are the major traditional system of medicine in Nepal. According to the WHO (1976) traditional medicine is the sum total of all knowledge and practices used in diagnosis, prevention, and treatment of diseased exclusively predicated on practical experience and observation handed over the generation whether verbally or in written form. Not only herbal medicines but also animal parts and/or minerals and nonmedication therapies are used in traditional medicine. Of the 10,091 species of higher plants found in Nepal, 700 species are believed to have medicinal values and only 238 species are medically tested and documented. Similarly, medicinal plants are traditionally used by several ethnic groups and communities under the guidance of Kavirajs, Vaidyas, Dhamis, Jhakris, Healers, and Lammas.[9,10] Over 100 Medicinal plants are being exported to other countries from Nepal and 70% of rural populations still rely on medicinal herbs for treatment.[11] Besides therapeutic uses, they also have nutritional, religious, cultural, and socioeconomic importance.

Pages 11-22
Year 2022
Issue 1
Volume 6

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February 19, 2026 In Uncategorized

msp.01.2022.06.10

TOTAL PHENOLIC CONTENT IN PIPER SARMENTOSUM USING DIFFERENT EXTRACTION TECHNIQUES AND SOLVENTS: A SHORT REVIEW

Journal: Matrix Science Pharma (MSP)
Maizatul Akma Ibrahim, Nuryn Imanina Kamarul Arifin, Nor Hazwani Mohd Hasali

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_7_22

ABSTRACT

Piper sarmentosum is an herbaceous plant that belongs to Piperaceae family which possesses an antioxidant activity due to the presence of phenolic compounds. The extraction of phenolic compounds from this Piper species could be carried out by employing various conventional and nonconventional extraction techniques and solvents. Among the extraction techniques commonly applied are maceration, infusion, reflux, and water bath extraction which are classified as conventional methods. Meanwhile, among nonconventional approaches employed are microwaved‑assisted extraction, ultrasonic‑assisted extraction (UAE), microwave‑assisted infusion, and agitation extraction. The recovery of phenolic content could be performed using different extracting solvents such as water, ethanol, methanol, butanol, hexane, n‑hexane, acetone, chloroform, and ethyl acetate. In this manuscript, the effect of different extraction techniques and solvents on the total phenolic content (TPC) in P. sarmentosum was reviewed. Previous research recorded that the TPC which was expressed as gallic acid equivalent in P. sarmentosum ranges from 0.57 mg GAE/g for UAE to 430 mg GAE/g where the maceration technique produced the highest TPC. While for the extracting solvents, methanol gave the most significant amount of TPC with obtained value at 379 mg GAE/100 g. This research provides an overall review of different techniques of solvents which could be used as references on the optimization of extraction processes to enhance the recovery of phenolic content from P. sarmentosum.

Pages 06-10
Year 2022
Issue 1
Volume 6

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February 19, 2026 In Uncategorized

msp.01.2022.01.05

PHARMACOTHERAPY OF MENIERE’S DISEASE: A REVIEW

Journal: Matrix Science Pharma (MSP)
Santosh Kumar Swain

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_5_22

ABSTRACT

Meniere’s disease (MD) is a chronic inner ear disorder characterized by intermittent episodes of vertigo lasting from minutes to hours, with fluctuating sensorineural hearing loss, tinnitus, and aural fullness. Endolymphatic hydrops is thought to be the pathological basis for MD and arise due to either excessive production or inadequate absorption of endolymph. The raised endolymphatic pressure causes periodic rupture or leakage in the membrane separating the endolymphatic from perilymphatic space. So, the treatment aims to reduce the production and increased the absorption of endolymph. The clinical objective of treatment is to stop vertigo spells, reduce or abolish tinnitus and preserve or even reverse hearing loss. The majority of the studies have focused on reducing vertigo attacks, which is the severest symptom of MD. There are several therapeutic options for MD, but none is considered effective by the scientific community. The prerequisites for successful pharmacotherapy for MD include correct diagnosis, correct drug, appropriate dosage, and appropriate duration of therapy. There are several groups of drugs that can be used for MD such as betahistine, oral corticosteroids, intratympanic corticosteroids, intratympanic gentamycin injections, and benzodiazepines. The objective of this review article is to discuss the current knowledge of the pharmacotherapy of MD. Appropriate treatment of MD prevents this morbid disease and improves the quality of life.

Pages 01-05
Year 2022
Issue 1
Volume 6

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February 19, 2026 In Uncategorized

msp.04.2021.89.95

EVALUATION OF HERBICIDAL PROPERTIES OF MIKANIA (MIKANIA MICRANTHA H.B.K) AND RAIN TREE (SAMANEA SAMAN JACQ MERR) LEAF EXTRACT

Journal: Matrix Science Pharma (MSP)
Md. Shariful Islam, Muslima Khatun, Md. Nizam Uddin, Md. Sharifur Rahman, Shah Md. Ashraful Islam Md. Khaled Saifullah

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_2_22

ABSTRACT

Weeds cause tremendous loss in crop yield and quality. In crop fields, weeds are one of the main pests reducing crop yield from 15% to 96%. In Bangladesh, weeds in crop fields are mainly controlled using labor. However, scarcity of agricultural laborers increases due to rapid industrialization. Hence, it is necessary to find out alternative ways to control weeds. One alternative is to use chemical herbicides which give rise to environmental hazards. Another option is to use of instrument to uproot weeds, but this is also difficult due to small size of land to apply different farm mechanization technology. Botanical herbicides have also been found to control weeds through utilizing the allelopathic potentials of these materials.

Pages 89-95
Year 2021
Issue 4
Volume 5

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February 19, 2026 In Uncategorized

msp.04.2021.84.88

A CASE STUDY OF MEDICINAL PLANTS AND THEIR USES BY THE SUNDAR HARAICHA NAGARPALIKA COMMUNITY IN MORANG DISTRICT, EAST NEPAL

Journal: Matrix Science Pharma (MSP)
Honey Raj Mandal, Shambhu Katel, Shulov Baidhya, Sujata Kattel, Amrit Katuwal

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_1_22

ABSTRACT

Nepal offers a wide range of meteorological and geographical conditions. As a result, it has a high floral richness, with over 6500 flowering plants and ferns, 2000 of which are regularly employed in traditional. Nepal is ranked 9th in terms of floral diversity. People mostly use medicinal plants and other natural products for their chemical and pharmacological properties. Medicinal plants played an essential part in agronomy and pharmacy throughout the 18th and 19th centuries since they provided raw materials for the pharmaceutical industry and were used as a medicine on a daily basis. People mostly use medicinal plants and other natural products for their chemical and pharmacological properties.

Pages 84-88
Year 2021
Issue 4
Volume 5

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February 19, 2026 In Uncategorized

msp.04.2021.77.83

CHEMICAL CONTENTS IN RELATION TO THE ANTIMICROBIAL EFFICACIES OF SOLANUM SPP. SECT. PETOTA

Journal: Matrix Science Pharma (MSP)
Adeyinka A. Aladesida, Adeyinka O. Adepoju, Bunmi Adesola‑Famade, Temitope Olushola Ajiboye, Tolulope A. Fagbolu

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_12_21

ABSTRACT

Since antiquity, plants have been employed not just as a source of food, clothing, and shelter but also for therapeutic use in traditional medicine. Over 1340 plants with defined antimicrobial activities are said to exist and over 30,000 antimicrobial compounds have been isolated from plants.[1,2] Plants which are used for therapeutic purposes are referred to as medicinal plants. Different parts of medicinal plants such as leaves, roots, rhizomes, stems, barks, flowers, fruits, grains, or seeds have been used to prevent and treat ailments; ranging from respiratory illnesses, urinary tract infection, gastrointestinal system illness as well as skin infections.[

Pages 77-83
Year 2021
Issue 4
Volume 5

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February 19, 2026 In Uncategorized

msp.03.2021.68.76

EXTRA VIRGIN OLIVE OIL NANOEMULSION ATTENUATED INFLAMMATORY RESPONSE IN LIPOPOLYSACCHARIDE‑INDUCED SEPSIS

Journal: Matrix Science Pharma (MSP)
Anna Surgean Veterini, Nancy Margarita Rehatta, Subijanto Marto Soedarmo, Heni Rachmawati, Widjiati, Widodo Jatim Pudjirahardjo, Annis Catur Adi, I Ketut Sudiana

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_11_21

ABSTRACT

The provision of nutritional components in critical illness such as sepsis remains a big issue in clinical application, particularly through oral route due to intestinal integrity damaged‑associated absorption problem. The aim of this research was to develop Extra Virgin Olive Oil (EVOO) nanoemulsion as a nutrient carrier to improve its permeability while maintaining the intestinal mucosa integrity in mouse model of lipopolysaccharide‑induced sepsis. EVOO nanoemulsion was prepared by using ultrasonication‑mild agitation method. EVOO nanoemulsion (1.5 mL) was administered to the mice through orogastric tube. The effect of EVOO nanoemulsion was evaluated by assessing the histopathological alterations in lung, measuring the activation of NFκB‑p65 by immunohistochemistry of lung tissue, the levels of circulating Surfactant Protein‑D (SP‑D), tumor necrosis factor‑alpha, interleukin (IL)‑8, and IL‑10. The main result, EVOO nanoemulsion decreased circulating SP‑D level after 24 h. In conclusion, EVOO nanoemulsion is a promising carrier to improve nutrition absorption and decrease circulating SP‑D as organ injury biomarker.

Pages 68-76
Year 2021
Issue 3
Volume 5

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February 19, 2026 In Uncategorized

msp.03.2021.54.59

TINOSPORA CORDIFOLIA: A MULTIPURPOSE MIRACLE PLANT HAVING MEDICINAL IMPORTANCE: A REVIEW

Journal: Matrix Science Pharma (MSP)
Santoshi Malla, Lal Bista

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_3_21

ABSTRACT

Medicinal plants are of great importance since the beginning of human civilizations. Popularity of medicinal plants is increasing year by year in plant‑based medicines, health products, pharmaceuticals, cosmetics, food supplements, etc., due to its well‑known properties along with its no side effects as compared to drugs. Tinospora cordifolia is commonly known as “Guduchi,” “Gurjo,” heart‑leaved moonseed,” or giloy. A chemical constituent present in various parts of T. cordifolia, their medicinal importance has risen up its popularity. Recently from the period of COVID‑19 pandemics, it is widely used to boost up immunity to fight against the coronavirus. This miracle plant is a shrub of vast Ayurvedic importance and is widely used in clinical research. This article had compiled diverse information regarding the identifications, chemical components present, pharmacological as well as Ayurvedic importance of T. cordifolia with a focus of it on recent occurred COVID pandemic as well

Pages 54-59
Year 2021
Issue 3
Volume 5

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February 19, 2026 In Uncategorized

msp.03.2021.60.67

ECOFRIENDLY ALTERNATIVES TO ANTIBIOTICS FOR IMPROVING GROWTH PERFORMANCE IN POULTRY

Journal: Matrix Science Pharma (MSP)
Ishwari Gyawali, Ramjee Paudel, Kailash Rayamajhi, Imtiyaz Ahmad Khan, Ghanashyam Dahal

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_14_20

ABSTRACT

Over more than six decades, dietary antibodies are used not solely to regulate infectious disease but conjointly to improve growth performance and feed potency. They are accountable for building the immunocompetence of poultry against several
infectious diseases. However, the use of antibiotics as feed additives, in the long run, can lead to the development of bacteria resistant to drugs that are used to treat infections. Later on, they are of potential risk if they are transferred to humans. In‑feed antibiotic (IFA) has played a substantial role in the advancement and prosperity of the poultry industry since its discovery. When antibiotic is administrated, it impacts the entire population of the body. Among the bacteria, some are susceptible to the antibiotics that die, but some bacteria may thrive, and they begin to multiply. Sometimes, these remaining bacteria are resistant to many antibiotics, and many large problems can develop. There exist significant concerns about the use of an IFA, which leads to the development of antimicrobial resistance, creating a potential menace to human health.

Pages 60-67
Year 2021
Issue 3
Volume 5

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