Matrix Science Pharma (MSP)

Parental Stress and Coping Strategy in Intensive Care Unit of North India: A Single‑Center, Prospective Observational Study

February 20, 2026 In Uncategorized

msp.04.2022.86.92

PARENTAL STRESS AND COPING STRATEGY IN INTENSIVE CARE UNIT OF NORTH INDIA: A SINGLE‑CENTER, PROSPECTIVE OBSERVATIONAL STUDY

Journal: Matrix Science Pharma (MSP)
Rahul Jaiswal, Sandhya Chauhan

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_12_22_1

ABSTRACT

Pediatric intensive care unit (PICU) is considered stressful environment and emotionally challenging for parents and care givers. Technological gadgetries, unfamiliar circumstances, fear of adverse outcomes, and monetary issues lead to their stress. The seriousness of the child’s illness, the criticality of the intensive care unit (ICU) environment, the changed parental relationship with the child, and the possible suddenness of the onset of the child’s illness may contribute to parental stress.

Pages 86-92
Year 2022
Issue 4
Volume 6

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February 20, 2026 In Uncategorized

msp.04.2022.81.85

ANTROCHOANAL POLYP: A NARRATIVE REVIEW

Journal: Matrix Science Pharma (MSP)
Santosh Kumar Swain

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_18_22_1

ABSTRACT

Antrochoanal polyp (ACP) is a benign lesion that originates from the mucosal lining of the maxillary sinus, growing through the accessory ostium into the middle meatus, and protruding posteriorly to the choana and nasopharynx. The etiopathogenesis of ACP is not clear. These are found more commonly in children and young adults. ACPs are almost always unilateral. The incidence of ACP is higher among children than in the adult population. Diagnostic nasal endoscopy and computed tomography scans are important investigations for the diagnosis of ACPs. During diagnostic nasal endoscopy, ACPs are typically seen as smooth, bluish, or yellowish mass extending posteriorly exiting from the ostium of the maxillary sinus. Simple polypectomy, Caldwell‑Luc procedure, and functional endoscopic sinus surgery may be employed for the surgical removal of the ACPs. Simple avulsions of the ACPs have a high rate of recurrence, whereas the Caldwell‑Luc procedure is often associated with injury to the maxillary and dental growth centers. Currently, functional endoscopic sinus surgery along with the use of powered instruments is used for the surgical removal of the ACPs. Incomplete excision of the ACP leads to the recurrence of the polyp. There are very smaller number of research articles describing the etiopathogenesis, clinical presentations, and current management protocol for ACPs, so this morbid clinical entity is not well known to most clinicians. This review article discusses the epidemiology, etiopathogenesis, clinical features, diagnosis, and current treatment of ACPs.

Pages 81-85
Year 2022
Issue 4
Volume 6

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February 20, 2026 In Uncategorized

msp.03.2022.75.80

THE EFFECT OF BETA-ALANINE SUPPLEMENTATION ON REDUCING BLOOD LACTATE CONCENTRATION AND IMPROVING SPORTS PERFORMANCE

Journal: Matrix Science Pharma (MSP)
Saiwan Sirwan Mohammed, Mohammed Rahman Rahimi, Dara Latif Sayfaddin

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_12_22

ABSTRACT

Intense exercise increases lactate levels. Muscle acidosis is mainly produced by anaerobic glycolysis and increasing adenosine triphosphate hydrolysis. It is theoretically considered the main environmental factor for muscle fatigue in high‑intensity training. Muscle acidosis leads to physiological disorders in reducing creatine phosphate and inhibiting essential enzymes such as phosphofructokinase in glycolysis. It also causes a decrease in the sensitivity of myofibrils to calcium ions and dysfunction of the muscle system. These physiological disorders can devastate speed and strength. The accumulation of H + ions is essential to fatigue.

Pages 75-80
Year 2022
Issue 3
Volume 6

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February 20, 2026 In Uncategorized

msp.03.2022.68.74

ANTIMICROBIAL ACTIVITIES OF THE SOFT‑TISSUE ETHANOLIC CRUDE EXTRACTS OF CORBICULID CLAM, CORBICULA FLUMINEA AND CYRENID CLAM, GELOINA EXPANSA

Journal: Matrix Science Pharma (MSP)
Marco F. De Guzman, Francis Albert T. Argente

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_9_22

ABSTRACT

The emergence of new infectious diseases and the increased in bacterial resistance of diseases transmitted between animals and humans have created studies to develop new antimicrobial drugs. The World Health Organization also reported that new diseases are emerging at a historically unprecedented rate causing at least 10 million deaths per year That leads to the search for more antimicrobial metabolites from natural sources, including the aquatic environment. Over 7000 bioactive marine compounds have been identified, analyzed, and isolated from different species of aquatic organisms. Several aquatic organism groups have been frontrunners in research that contain bioactive metabolites, and mollusks are becoming a promising source of new compounds. The priority list of species exhibiting antimicrobial activity includes several mollusks. Several species of bivalves have been reported with antimicrobial activities, like oyster Crassostrea madranensis, mussel Perna veridis, and clam Polymesoda expansa.

Pages 68-74
Year 2022
Issue 3
Volume 6

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February 20, 2026 In Uncategorized

msp.03.2022.62.67

ETHNOBOTANICAL STUDY OF WILD EDIBLE PLANTS IN PYUTHAN DISTRICT

Journal: Matrix Science Pharma (MSP)
Sangam Patna, Dipika Parajulee, Ganesh Subedi, Bhuwan Giri

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_7_21

ABSTRACT

Nepal, being a small country, occupying just 0.1% of the global area is rich in its biodiversity, both in plant and animal diversity and cultural diversity. The country is bestowed with climatic variation and unique geography which provides diversified topography. The ecologically rich environment and the multi‑ethnic population is a unique and attractive attribute of the country. Biodiversity and cultural diversity come together as we know; different ethnic groups depend on biodiversity for their food security. Nepal is rich in wild edible plants (WEPs) growing in different ecosystems and such plants along with their wild relatives enrich the genetic diversity in the country.

Pages 62-67
Year 2022
Issue 3
Volume 6

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February 20, 2026 In Uncategorized

msp.03.2022.58.61

MEDICAL TREATMENT OF RHINITIS IN PREGNANT WOMAN

Journal: Matrix Science Pharma (MSP)
Santosh Kumar Swain

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_10_22

ABSTRACT

Rhinitis is a global problem and is described as the presence of at least one of the symptoms, such as sneezing, rhinorrhea, nasal itching, and nasal obstruction. Gestational rhinitis is a common clinical condition found during pregnancy. Medical management options for pregnant women with rhinitis need careful consideration. It is often challenging to differentiate the causes of rhinitis as it often influences the treatment. Conservative treatment is an important option for patients with pregnancy‑induced rhinitis and preexisting allergic or nonallergic rhinitis. Awareness about pregnancy‑induced rhinitis and its resolve after pregnancy can provide some relief. Few options, such as exercises, nasal douching or lavage, positioning, and nasal valve dilators, are safe in pregnancy with rhinitis due to any etiology. Intranasal corticosteroids have often safe with budesonide. Oral corticosteroids can be used in pregnant women with moderate‑to‑severe disease and should be avoided in the first trimester. Second‑generation antihistamines, such as loratadine and cetirizine, are the most well‑studied drugs, and are often considered safe. The role of immunotherapy requires further research to establish its effectiveness. Hence, the treatment of rhinitis during pregnancy is considered a complex task. This review article aims to discuss the current medical treatment options for rhinitis during pregnancy.

Pages 58-61
Year 2022
Issue 3
Volume 6

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February 20, 2026 In Uncategorized

msp.03.2022.53.57

CURRENT PHARMACOLOGICAL TREATMENT OF TINNITUS

Journal: Matrix Science Pharma (MSP)
Santosh Kumar Swain, Debasmita Dubey

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_11_22

ABSTRACT

Tinnitus is the phantom perception of sound. The pathophysiology of tinnitus is poorly understood in medicine. It is a highly prevalent disorder and treatment is still elusive. Tinnitus is a common otologic symptom presented by patients in the outpatient department of otolaryngology. In some people, tinnitus is a fairly minor irritation but for many, it intrudes to such a degree that it affects their ability to lead a normal life. Individuals who suffer from disabling tinnitus often need medical treatment from an otologist, neurologist, or psychiatrist with the hope of finding a medication that can completely switch off their tinnitus and bring back silence. The available treatment for tinnitus patients is diverse. These include counseling, cognitive behavioral therapies, tinnitus retraining therapy, and input to the auditory system such as hearing aids and cochlear implants. The pharmacological treatment for tinnitus patients is often less discussed in the literature. The search for effective tinnitus treatment faces considerable challenges. Tinnitus is only a symptom that might be the result of different underlying pathologies. Thus, heterogeneity within tinnitus patients is expected and the drug discovery endeavor faces a “one drug will not fit all” scenario. Tinnitus today is still clinically challenging and most patients want a drug that could reduce or even abolish their phantom sound. The objective of this review article is to discuss the current pharmacological treatment of tinnitus.

Pages 53-57
Year 2022
Issue 3
Volume 6

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February 20, 2026 In Uncategorized

msp.02.2022.46.52

CYTOTOXIC AND APOPTOTIC INDUCTION ACTIVITY OF PROTEIN ISOLATED FROM BLOOD CLAM (ANADARA (TEGILLARCA) GRANOSA, LINNAEUS 1758) AGAINST BREAST CANCER T47D CELL LINE

Journal: Matrix Science Pharma (MSP)
Faruk Rokhman Ardi Putra, Rebekah J Setyabudi, Nastiti Wijayanti, Theresia Indah Budhy S

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_9_21

ABSTRACT

Cancer is the second‑leading cause of death in the world. Recently, it has been estimated that 10 million people have died due to cancer. Breast cancer is the highest type of cancer found in women with cancer by the WHO, 2021. The maturation of cancer cells through various processes and involves various types of cells. Therefore, the early detection and elimination of these cells is a promising way to overcome the problem of the spread of cancer cells. Breast cancer can be started from the formation of a tumor in the duct gland which undergoes unlimited division to form a tumor which is then able to develop into cancer. This development can be initiated by mutations that occur in oncogene genes such as human epidermal growth factor 2 (HER2) and estrogen receptors.[3] The mechanism of development and spread of tumors into cancer in breast cells is influenced by a microclimate based on inflammatory events and the avoidance of macrophages. This process triggers the malignancy of cancer cells.

Pages 46-52
Year 2022
Issue 2
Volume 6

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February 20, 2026 In Uncategorized

msp.02.2022.41.45

ANTI-INFLAMMATORY, VIRAL REPLICATION SUPPRESSION AND HEPATOPROTECTIVE ACTIVITIES OF BITTER KOLA – LIME JUICE, – HONEY MIXTURE IN HBEAG SEROPOSITIVE PATIENTS

Journal: Matrix Science Pharma (MSP)
Mathew Folaranmi Olaniyan, Ferdinand Uwaifo, Tolulope Busayo Olaniyan

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_8_22

ABSTRACT

Sweetness Interleukin 10 (IL‑10) cytokine is a human cytokine synthesis inhibitory factor and an anti‑inflammatory cytokine. It inhibits the production of pro‑inflammatory cytokines. IL‑10 cytokine an anti‑inflammatory cytokine enhances B cell survival and proliferation. It stimulates antibody production. IL‑10 cytokine suppresses antigen‑presenting cells regarding
antigen‑presentation capacity.

Pages 41-45
Year 2022
Issue 2
Volume 6

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February 20, 2026 In Uncategorized

msp.02.2022.35.40

MOLECULAR IDENTIFICATION AND PHYLOGENETIC ANALYSIS OF PUTATIVE SENESCENCE ASSOCIATED GENE 21 IN STEVIA REBAUDIANA ACCESSION MS007

Journal: Matrix Science Pharma (MSP)
Nur Farhana Mustafa, Siti Noor Eliana Mohamad Nazar, Zabirah Abdul Rahim, Nurul Hidayah Samsulrizal

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_6_22

ABSTRACT

Sweetness is one of the taste sensations that allow humans to savor foods. It is highly related to sugar as it gives a sweet taste to the dishes. Alot of research has been done to find alternative resources for sweeteners aside from sugarcane and honey. Stevia has been one of the natural sweeteners that can replace
sugar in our food intake. In Japan, Stevia has been widely used as a sweetener in food and beverages. Steviol glycosides(SGs) are the compounds present in Stevia which give the food a sweet taste. The main components of SGs are stevioside and rebaudioside A. These components are highly soluble in water and have intensely sweet properties.[2] Researchers have found that stevioside is 300 times sweeter than sucrose.

Pages 35-40
Year 2022
Issue 2
Volume 6

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