Matrix Science Pharma (MSP)

Phytochemical Screening and Anti‑inflammatory, Antioxidant, and Antimicrobial Investigations on Extracts of Ixora javanica

February 20, 2026 In Uncategorized

msp.02.2023.43.51

PHYTOCHEMICAL SCREENING AND ANTI‑INFLAMMATORY, ANTIOXIDANT, AND ANTIMICROBIAL INVESTIGATIONS ON EXTRACTS OF IXORA JAVANICA

Journal: Matrix Science Pharma (MSP)
Avijit Chaterjee, Debarati Chaterjee, Manik Ghosh, Pankaj Dagur, Jashanpreet Kaur, Naresh Kumar Rangra, Suddhasattya Dey, Arijit Mondal, Alindam Ghosh, Padmacharan Behera

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_2_23

ABSTRACT

Medicinal plants are the oldest source of essential medicines useful for human diseases because of their significant therapeutic value. The medicinal plants possess an exceptionally huge place as crude material for critical use of medications. They enclose phytoconstituents, which are utilized in the cure of numerous human diseases. Plants are considered an abundant source of environmentally created optional metabolites, which are powerful solutions for various diseases. A critical problem in pharmacotherapeutics is emerging in the form of multiple drug resistance. However, medicinal plants are considered rich sources for antimicrobial agents.[1] Hence, phytochemical evaluation of diverse plant species for medicinal leads to gain much consideration.

Pages 43-51
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.36.42

THE INTERSECTION OF ARTIFICIAL INTELLIGENCE AND BIG DATA IN DRUG DISCOVERY: A REVIEW OF CURRENT TRENDS AND FUTURE IMPLICATIONS

Journal: Matrix Science Pharma (MSP)
Bankole Ibrahim Ashiwaju, Ochuko Felix Orikpete, Chinedum Gloria Uzougbo

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_14_23

ABSTRACT

The pharmaceutical landscape has been continually evolving, adapting to the myriad technological advancements of the 21st century. Among these innovations, artificial intelligence (AI) and big data have emerged as transformative tools, altering the trajectory of drug discovery processes. This review elucidates the symbiotic relationship between AI and big data in modern drug discovery, highlighting the profound enhancements in efficiency, precision, and innovation. Drawing from current research trends, we delve into the potent capabilities of AI‑powered algorithms to process, analyze, and glean insights from massive, multifaceted datasets. Furthermore, we explore the tangible impacts on drug repurposing, predictive modeling, molecular simulation, and clinical trials. Yet, this merger is not devoid of challenges. The review also critically examines inherent obstacles such as data integrity, the interpretability of AI models, and the evolving regulatory frameworks. As we gaze into the future of drug discovery, this intersection of AI and big data offers promising horizons, with implications not only for faster, more precise drug development but also for personalized, efficient patient care. This article aims to provide a comprehensive perspective on the current landscape while forecasting the transformative potential in the upcoming decades.

Pages 36-42
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.27.35

AN EXPERIMENTAL STUDY: THE EFFECT OF GARCINIA KOLA ON SUPEROXIDE DISMUTASE, CATALASE, AND LIPID PEROXIDATION LEVELS IN THE KIDNEY OF MICE

Journal: Matrix Science Pharma (MSP)
Chinedum Gloria Uzougbo, Bankole Ibrahim Ashiwaju

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_13_23

ABSTRACT

Garcinia kola is a tropical plant with various traditional medicinal uses, and its potential effects on antioxidant enzymes and lipid peroxidation make it a subject of interest for scientific investigation. This study was conducted over 2 months and 6 days to investigate the effect of consuming G. kola on catalase and superoxide dismutase (SOD) activities and lipid peroxidation levels in the kidney of mice. Twelve female albino mice were divided into four groups, each consisting of three. Group 1 (control) received only growers mash, while groups A, B, and C were fed diets containing 1%, 3%, and 6% G. kola, respectively. The study revealed that mice fed with 1% G. kola exhibited a significant increase in SOD activity in their kidneys compared to other experimental groups. However, no significant changes were observed in catalase activity and lipid peroxidation levels among all the experimental groups. These findings suggest that dietary consumption of G. kola appears to be nontoxic to mice.

Pages 27-35
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.01.2023.22.26

PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF ZANTHOXYLUM ACANTHOPODIUM DC. ESSENTIAL OILS

Journal: Matrix Science Pharma (MSP)
Eldiza Puji Rahmi, Feda Anisah Makkiyah, Abdi Wira Septama, Aprilia Nur Tasfiyati, Rizna Triana Dewi

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_9_23

ABSTRACT

In recent years, it has become increasingly evident that herbal remedies can effectively cure inflammatory and oxidant‑related diseases. Oxidative stress contributes significantly to the development of age‑related and degenerative diseases, such as cancer, diabetes, cardiovascular disease, atherosclerosis, and neurodegenerative diseases. The body produces enzymatic and nonenzymatic antioxidant defenses, whereas other antioxidants are received through the diet. Together, these defenses transform free radicals into nonreactive forms. Among these, the potential antioxidant properties of plant essential oils have been explored. Plant essential oils contain these capacities, which can be related to the existence of terpenes and phenolic components that contribute to free radical scavenging action

Pages 22-26
Year 2023
Issue 1
Volume 7

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February 20, 2026 In Uncategorized

msp.01.2023.17.21

IDENTIFICATION AND CONTENT DETERMINATION OF TOXIC ALKALOIDS IN ACONITUM BRACHYPODUM

Journal: Matrix Science Pharma (MSP)
Haiyan Peng, Fulin Yang, Yumei Luo, Xiaoxia Ma, Zhihong Zhou

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_6_23

ABSTRACT

Aconitum brachypodum, also known as Yi-zhi-hao or Tie￾bang-chui, is a dried tuber of the herbaceous plant Aconitum, belonging to the family Ranunculaceae. It is also mainly distributed in the northeast and northwest regions of Yunnan Province, as well as the southwestern region of Sichuan Province,[1‑3] and has been widely used in pain management. Studies have shown that its primary active ingredient is alcohol, amine, and alkaloids, while its main source of toxicity is from diester alkaloids.[4‑8] However, the quality standards for Aconitum brachypodum medicinal herbs and its preparations, such as tablets and total alkaloid injections,
have not yet described or quantified its toxic components.[9‑11] Failure to effectively control the toxicity of this highly toxic herb would pose significant risks to clinical use. A study of its chemical components[12] revealed that its diester alkaloids primarily include aconitine and its derivatives, such as hypaconitine, 3‑deoxyaconitine, N‑deethyl‑3‑acetylaconitine, N‑deethylaconitine, and 15‑deoxyhypaconitine. These chemical structures are similar to aconitine, characterized by acetylation at the 8‑hydroxyl position and benzoylation at the 14 position, resulting in the ease of nitrogen atom dissolution in acidic water and small molecular polarity that can be easily extracted into organic solvents. For the first time, this study utilized these structural features to qualitatively identify and quantitatively determine the toxic components in Aconitum brachypodum, providing scientific support for quality control of medicinal herbs and preparations, as well as safe clinical use.

Pages 17-21
Year 2023
Issue 1
Volume 7

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February 20, 2026 In Uncategorized

msp.01.2023.10.16

RETROSPECTIVE DRUG UTILIZATION REVIEW OF ANTIBIOTICS USED IN A GOVERNMENT HOSPITAL IN KEDAH, MALAYSIA

Journal: Matrix Science Pharma (MSP)
Chew Yi Jean, Sam Aaseer Thamby, Ganesh Pandian Balasubramanian, Sireesha Paruchuri

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_4_23

ABSTRACT

Drug utilization evaluation (DUE) or review is a systematic process aimed to evaluate the drug(s) usage and prescribing pattern(s). It can assist in ensuring that the medications are used in a rational manner. DUE is conducted before, throughout, and after medications dispensing, to ensure that rational decisions are made with positive outcomes for the patients.[1] DUE is defined as authorized, structured, and on‑going review with the prescribing of physician, dispensing of pharmacist, and the medications used by the patient.

Pages 10-16
Year 2023
Issue 1
Volume 7

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February 20, 2026 In Uncategorized

msp.01.2023.07.09

REVIEW ON MAJOR BIOACTIVE AGENTS ALONG WITH TRADITIONAL AND MEDICINAL USES OF MALUS DOMESTICA

Journal: Matrix Science Pharma (MSP)
Prakash Awasthi, Rashmita Thakuri

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_8_23

ABSTRACT

Because they have fewer negative effects than chemical medications, fruit‑derived bioactive compounds have gained attention as a regulator against a variety of diseases. Apple is one of the most popular fruits, a rich source of nutritional components, and has high amounts of bioactive substances. Pentacyclic triterpenes, phytosterols, polysaccharides(pectin), and polyphenols are the main structural classes of apple components. The nutritional benefits of apples are completed by vitamins and trace elements. These bioactive compounds found in apples and their peels can promote human health by reducing the risk of cancer, diabetes, inflammation, and cardiovascular disease. This is supported by a growing body of scientific research. The present understanding of apple bioactive compounds and their potential medical benefits for people’s health will be the main emphasis of this review.

Pages 07-09
Year 2023
Issue 1
Volume 7

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February 20, 2026 In Uncategorized

msp.01.2023.01.06

IMMUNE‑BOOSTING PHYTOCHEMICALS IN NIGERIA

Journal: Matrix Science Pharma (MSP)
Mathew Folaranmi Olaniyan, Musa Abidemi Muhibi, Tolulope Busayo Olaniyan

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_5_23

ABSTRACT

The immune‑boosting potential of phytochemicals from plant products in Nigeria has gained significant attention in recent years. Phytochemicals are bioactive compounds found in plants that have been shown to possess immunomodulatory properties. Nigeria is a country with rich biodiversity, and its traditional medicine practices rely heavily on the use of plant products for various health purposes, including immune enhancement. This review aims to summarize the existing literature on immune‑boosting phytochemicals in Nigeria and their activities. Relevant and accurate literature were sourced from WHO. CDC, NCDC, PubMed, Scopus, PLoS One Crossref, Google Scholar, and NATURE Journals. Several studies have identified various phytochemicals with immunomodulatory properties from Nigerian medicinal plants, including alkaloids, flavonoids, terpenoids, phenolic compounds, and polysaccharides. These phytochemicals have been shown to exhibit diverse mechanisms of action, such as antioxidant, anti‑inflammatory, antimicrobial, and immunostimulatory activities, which can potentially support the immune system and improve overall health. However, there are still knowledge gaps that need to be addressed in this field. Further research is needed to elucidate the molecular mechanisms underlying the immunomodulatory activities of these phytochemicals and their safety and efficacy in human subjects. To ensure consistency and reproducibility of results, it is crucial to standardize the methods used for extracting, isolating, and characterizing phytochemicals from Nigerian plant products. Quality control measures must also be put in place. Moreover, studies on the sustainable sourcing, cultivation, and conservation of medicinal plants in Nigeria are crucial to ensure their availability for future generations. Bridging these knowledge gaps will facilitate the development of evidence‑based interventions using immune‑boosting phytochemicals from Nigerian plant products for the management of immune‑related health conditions. Further exploration of the immunomodulatory potential of Nigerian plant products and their phytochemicals has the potential to contribute to the development of novel strategies for enhancing immune function and improving overall health.

Pages 01-06
Year 2023
Issue 1
Volume 7

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February 20, 2026 In Uncategorized

msp.04.2022.97.104

PREDICTORS OF FAMILY LIFE AND HUMAN IMMUNODEFICIENCY VIRUS EDUCATION AMONG SECONDARY SCHOOL STUDENTS IN A SOUTHWESTERN METROPOLIS, NIGERIA

Journal: Matrix Science Pharma (MSP)
Taiwo A. Obembe, Tolulope Adeola Fagbolu, Ibukunoluwa Elizabeth Okunade

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_11_22_1

ABSTRACT

Sexuality among young adults is an ever‑increasing sensitive topic that must be handled by not only teachers and parents, but by role models in every community. Deficient ownership or control of this topic can tilt teens and young adults to seek answers from random persons or media that place very little emphasis on their physiological and psychological developments, in many instances leading to fatal and detrimental consequences. Schools and formal educational environments are known to be a major source of information and avenue of instruction for young adults. For about the three decades, many developing countries have witnessed an immense improvement in enrolment rates in schools with about 1.2 billion people of the world population, adolescents aged 10–19 years, making up the global secondary school population.

Pages 97-104
Year 2022
Issue 4
Volume 6

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February 20, 2026 In Uncategorized

msp.04.2022.93.96

COMPARISON OF BUPIVACAINE AND LIDOCAINE IN THE TREATMENT OF POSTTONSILLECTOMY PAIN IN PEDIATRIC PATIENTS: OUR EXPERIENCES

Journal: Matrix Science Pharma (MSP)
Santosh Kumar Swain, Ansuman Sahu

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_17_22_1

ABSTRACT

Tonsillectomy is a common surgical procedure in the pediatric age group and is often associated with postoperative pain which may challenge the clinician. Children may become
restless or crying due to pain, hunger, or fear after surgery, particularly tonsillectomy. Pain after tonsillectomy is the major impediment to a patient’s recovery, affecting the length of hospital stay and capacity to resume the normal activities. The important factors which decide the postoperative outcomes include pain, nausea, vomiting, anxiety before surgery, and discomfort by intravenous injection. It has been seen that more than 60% of the pediatric patients those underwent tonsillectomy exhibit negative behavioral changes in the next weeks after surgery.[4] Hence, it is critical to administer appropriate postoperative analgesics. Many otolaryngologists believe that the discomfort is worst between days 3 and 5 after tonsillectomy. However, there is no such evidence to support this.

Pages 93-96
Year 2022
Issue 4
Volume 6

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