AN EXPERIMENTAL STUDY: THE EFFECT OF GARCINIA KOLA ON SUPEROXIDE DISMUTASE, CATALASE, AND LIPID PEROXIDATION LEVELS IN THE KIDNEY OF MICE
Journal: Matrix Science Pharma (MSP)
Chinedum Gloria Uzougbo, Bankole Ibrahim Ashiwaju
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
ABSTRACT
Garcinia kola is a tropical plant with various traditional medicinal uses, and its potential effects on antioxidant enzymes and lipid peroxidation make it a subject of interest for scientific investigation. This study was conducted over 2 months and 6 days to investigate the effect of consuming G. kola on catalase and superoxide dismutase (SOD) activities and lipid peroxidation levels in the kidney of mice. Twelve female albino mice were divided into four groups, each consisting of three. Group 1 (control) received only growers mash, while groups A, B, and C were fed diets containing 1%, 3%, and 6% G. kola, respectively. The study revealed that mice fed with 1% G. kola exhibited a significant increase in SOD activity in their kidneys compared to other experimental groups. However, no significant changes were observed in catalase activity and lipid peroxidation levels among all the experimental groups. These findings suggest that dietary consumption of G. kola appears to be nontoxic to mice.
| Pages | 27-35 |
| Year | 2023 |
| Issue | 2 |
| Volume | 7 |
