Matrix Science Pharma (MSP)

Mutagenesis of Cellulose Synthase (CesA‑Like) Gene in Tomato Using Clustered Regularly Interspaced Short Palindromic Repeat/CAS9‑System

February 13, 2026 In Uncategorized

msp.02.2019.43.46

MUTAGENESIS OF CELLULOSE SYNTHASE (CESA‑LIKE) GENE IN TOMATO USING CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT/CAS9‑SYSTEM

Journal: Matrix Science Pharma (MSP)
Author: Nurul Hidayah Samsulrizal

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_11_19

ABSTRACT

Objectives: To better understand the relationship between cell wall remodelling and fruit softening, an understanding of cell wall structure is necessary. Methods: Cellulose synthase gene that consists of cellulose synthase (CesA-like) plays important role in cellulose biosynthesis. However, CesA family genes are yet to be fully characterized in Solanaceae species. Results: In this study, we generated transgenic plants to test the role of CesA like gene in texture changes using tomato (Solanum lycopersicum) as a model system. We used the recently developed clustered regularly interspaced short palindromic repeat/Cas9 DNA editing technology to generate mutations in the target gene. Conclusions: Nevertheless, there was no mutation recovered in the CesA-like gene, and this indicates that this gene product is likely essential for regeneration of plantlets from tissue culture.

Pages 43-46
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.40.42

STUDY ON THE EFFECT OF MUSIC THERAPY ON PSYCHOLOGICAL INTERVENTION OF PATIENTS AFTER OPERATION

Journal: Matrix Science Pharma (MSP)
Author: Y. Zhang, L. L. Sun

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_7_19

ABSTRACT

Objectives: The objective was to explore the effect of music therapy on psychological intervention of patients after operation. Methods: The patients were divided into observation group and control group with an average of 68 patients after the outpatient operation. Routine psychological nursing was administered to the patients after operation in the control group and patients in the observation group were administered music therapy on the basis of routine psychological nursing. The psychological anxiety value of the two groups of patients was assessed by Zung Self‑Rating Anxiety Scale. At the same time, the blood pressure, pulse, and pain of the two groups of patients were compared. Results: The blood pressure, pulse, and pain degree of the patients in the observation group were better than those in the control group. The psychological anxiety value of the two groups was statistically significantly better than that of the control group (P < 0.05). Conclusions: Music therapy has an important influence on the psychological intervention of postoperative patients. Patients’ psychological anxiety can be reduced by the use of music therapy at the same time will reduce the psychological anxiety of the patients, improve the psychological status of the patients, help the patients to maintain the stability of vital signs and help the patients recover after operation.

Pages 40-42
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.37.39

STUDY ON THE DIFFERENCE OF WEIGHT REDUCTION EFFECT BETWEEN HIGH‑INTENSITY INTERVAL TRAINING AND PERSISTENT AEROBIC EXERCISE FOR FEMALE COLLEGE STUDENTS

Journal: Matrix Science Pharma (MSP)
Author: Y. Zhang, L. L. Sun

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_6_19

ABSTRACT

Objectives: The aim was to study the effect of persistent aerobic exercise and high‑intensity interval training (HIIT) on weight loss of female students. Methods: Seventy‑two college students were selected as the research subjects, and they were randomly divided into the control group and the observation group. Thirty‑six cases in the control group were doing the persistent aerobic exercise and 36 in the observation group were using the HIIT weight loss method. The waist‑to‑hip ratio, body weight, and body fat were observed and recorded in two groups. Results: The waist‑to‑hip ratio of female students in the control group was significantly lower than that in the observation group, and the difference between the two groups was statistically significant (P < 0.05). The weight loss rate of female college students in the observation group was significantly higher than that in the control group, and the difference between the two groups was statistically significant (P < 0.05). The changes in body fat in female college students in the control group were significantly greater than those in the control group, and the difference between the two groups was statistically significant (P < 0.05). Conclusions: Compared with the continuous aerobic exercise method, the HIIT weight‑loss method has a more significant effect on female college students’ weight loss and has a certain safety

Pages 37-39
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.31.36

ASSESSMENT OF NUTRITIONAL STATUS OF UNDER 5‑YEAR‑OLD CHILDREN IN BANADIR HOSPITAL, MOGADISHU, SOMALIA

Journal: Matrix Science Pharma (MSP)
Author: Abdikadir Ahmed Omar, Nadira Mehriban

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_12_19

ABSTRACT

Objectives: Nutritional status of children is a proxy indicator for assessing the entire population health status and one of the major predictors of child survival. Despite the various efforts, malnutrition among children is remaining as a major public health problem in Somalia. The study objective was to assess the nutritional status of under 5‑year‑old children in Banadir Hospital, Mogadishu, Somalia. Methods: A descriptive cross‑sectional study was conducted among 150 under‑five children. Sociodemographic characteristic, usual dietary intake and assess adequacy, breastfeeding and complementary feeding pattern of the mothers, and anthropometric index of the children were collected by using semi‑structured questionnaire. Results: Age categorized into 0–1 years old were 52.7%, 32.0% were 1–2 years old, 8.7% were 3–4 years old, and 6.7% were 4–5 years old. With mean and standard deviation of 17.44 ± 13.096, the age was the most critical variable because it was one of the scales of the Mental Adjustment to Cancer (MAC) measurements and target objective of the study. MAC test showed that 49.3% of the children were severe, 16.0% of the children were mild malnourished, and 34.7% of the children were well‑nourished children. Based on height‑for‑age chronic malnutrition, 16.0% of the respondents were severe, 14.7% of the respondents were moderate, 24.0% of the respondents were mild, and 45.3% of the respondents were normal. According to the weight‑for‑height acute malnutrition, 30.7% of the respondents were severe, 19.3% of the respondents were moderate, 10.7% of the respondents were mild, and 39.3% of the respondents were normal. Conclusions: The findings showed that the nutritional status of under‑five children was quite poor. Also from the results, it is evident that malnutrition is still a major public health problem among young children due to the poor socioeconomic status (poverty and poor educational background) of their parents, and thus, there is a need for better nutrition of the Somali child.

Pages 31-36
Year 2019
Issue 2
Volume 3

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February 13, 2026 In Uncategorized

msp.02.2019.26.30

ASSESSING THE KNOWLEDGE OF PRIVATE UNIVERSITY STUDENTS ON SELF‑MEDICATION PRACTICES, MALAYSIA

Journal: Matrix Science Pharma (MSP)
Author: Ganesh Pandian B, Sireesha P, Ng Y. P, S. Devan Raj, Law C. Y, Patrick C. E. M

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_13_19

ABSTRACT

Objectives: Self‑medication is usually defined as an intake of any type of drugs for treatment without professional supervision to relieve an illness or a condition. College students prefer self‑medication for minor illness to save time and money. The study aimed at assessing the knowledge on self‑medication practice among medical and nonmedical university students. Methods: It is a prospective observational study and a total of 579 individuals were included. Study participants were selected by stratified random sampling from various faculties of a private university campus. Study population was divided into two groups as medical and nonmedical based on their faculty they belong to. A prevalidated questionnaire was used to assess the knowledge on self‑medication practices. Questionnaire was distributed, and various data regarding their self‑medication practice were collected and the collected data were analyzed using Chi‑square test. Results: The collected data showed that the knowledge of medical students on self‑medication was better than the nonmedical group, and the study participants staying at hostel use over the counter (OTC) s more than the others. Conclusions: Self‑medication practice was common among the university students which show the need for education regarding the rational use of OTCs. By doing this, the drug‑related problems can be avoided and OTCs can be rationally utilized.

Pages 26-30
Year 2019
Issue 2
Volume 3

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February 12, 2026 In Uncategorized

msp.01.2019.23.25

THE STUDY OF DIFFERENTIALLY EXPRESSED SERUM PROTEIN IN PATIENTS WITH DIFFERENT TRADITIONAL CHINESE MEDICINE SYNDROMES OF KNEE OSTEOARTHRITIS

Journal: Matrix Science Pharma (MSP)
Author: Y. B. Zhou, Z. Y. Dong, Y. J. Deng, Q. C. Meng

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_10_19

ABSTRACT

Objectives: To study the distribution characteristics of patients with knee osteoarthritis(KOA) of different traditional Chinese medicine (TCM) syndromes and to reveal the differences from the perspectives of expressions of serum inflammatory indicators. Methods: One hundred and thirty‑four patients with KOA treated in our hospital from January 2013 to March 2016 and referring to TCM syndrome types were included in the study and were divided into three types: Yin deficiency in kidney and liver\tendon and vesselstasissyndrome,s pleen and kidney deficiency\ wet injection the osteomere syndrome, kidney Yang deficiency and weak\phlegm stasis syndrome; 24 healthy persons who took physical examination in our hospital were selected as the normal control group. Patients’ blood was collected in the morning as the blood samples, and the levels of inflammatory factors (5‑TH, interleukin‑6 [IL‑6], and tumor necrosis factor‑α [TNF‑α]) were measured in serum. Results: The most common TCM syndrome of KOAin the clinical trialsis Yin deficiency in kidney and liver\tendon and vesselstasissyndrome, the percents of spleen and kidney deficiency\wet injection the osteomere syndrome and kidney Yang deficiency and weak\phlegm stasissyndrome are near, the former is slightly higher than the latter by 3.97%. The levels of IL‑6 and TNF‑α in the three groups were significantly higher than those in the normal control group, whereas the 5‑TH level was significantly lower in the three groups than that in the normal control group (P < 0.05). The levels of IL‑6 and TNF‑α in the kidney Yang deficiency and weak\phlegm stasis syndrome group were significantly higher than the next two TCM syndrome groups (P < 0.05), whereas the 5‑TH level in the kidney Yang deficiency and weak\phlegm stasis syndrome group was significantly lower than the next two TCM syndrome groups (P < 0.05). Conclusions: Yin deficiency in kidney and liver\tendon and vessel stasis syndrome is the most common TCM syndrome of KOA in the clinical trials. The levels of inflammatory factors (5 TH, IL 6, and TNF α) in serum had a close relationship with KOA. In terms of the perspectives of expressions of serum inflammatory indicators, the most serious TCM syndrome of KOA is kidney Yang deficiency and weak\phlegm stasis syndrome.

Pages 23-25
Year 2019
Issue 1
Volume 3

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February 12, 2026 In Uncategorized

msp.01.2019.19.22

THE DIAGNOSTIC EFFICACY OF URINARY VASCULAR ENDOTHELIAL GROWTH FACTOR IN EARLY STAGE 2 DIABETIC NEPHROPATHY

Journal: Matrix Science Pharma (MSP)
Author: Pang LL

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_9_19

ABSTRACT

Objectives: The objective was to analyze the application of vascular endothelial growth factor (VEGF) in the diagnosis of early type 2 diabetic nephropathy (DN). Methods: Thirty‑eight patients with type 2 DN diagnosed and treated from March 2016 to August 2017 were selected as the study group and another 38 healthy controls were selected as the control group. The two groups were examined by enzyme‑linked immunosorbent assay. Two groups of VEGF, serum creatinine, and glycosylated hemoglobin were observed and recorded. Results: Compared with the control group, the VEGF was higher in the observation group, and there was statistically significant difference between the two groups (P < 0.05). Compared with the control group, the specificity of serum creatinine and glycosylated hemoglobin was more significant in the observation group, and there was statistically significant difference between the two groups (P < 0.05). Conclusions: The application of urinary VEGF in the early diagnosis of type 2 DN has some clinical diagnostic value.

Pages 19-22
Year 2019
Issue 1
Volume 3

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February 12, 2026 In Uncategorized

msp.01.2019.16.18

STUDY ON THE EFFECT OF SINGLE EXERCISE INTERVENTION ON STUDENTS WITH IMPAIRED GLUCOSE TOLERANCE

Journal: Matrix Science Pharma (MSP)
Author: K. W. Dong, X. X. Xue

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_8_19

ABSTRACT

Objectives: The aim of this study is to study the effect of single exercise intervention on students with impaired glucose tolerance (IGT). Methods: In this study, 25 patients with low glucose tolerance in a university in JX were selected as the study participants and randomly divided into control group and observation group. In the control group, 12 cases were treated with routine motion intervention, whereas 13 cases in the observation group were treated with single exercise intervention of moderate‑intensity level running. The training period was 15 weeks, six times a week, and 2 h a time. Moreover, two groups of IGT students’ glycated hemoglobin level, waist circumference, and insulin were observed and recorded. Results: Compared with the control group, the insulin level in the observation group was significantly lower than that in the control group, and the difference between the two groups was statistically significant (P < 0.05). The level of hemoglobin in the observation group was significantly lower than that of the control group, and there was significant difference between the two groups(P < 0.05). The waist circumference of the observation group was significantly lower than that of the control group. There was a significant difference between the two groups (P < 0.05). Conclusions: Single-phase motion intervention can effectively reverse the decrease of sugar content of college students and has certain application value.

Pages 16-18
Year 2019
Issue 1
Volume 3

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February 12, 2026 In Uncategorized

msp.01.2019.12.15

RESEARCH ON THE INFLUENCE MECHANISM OF WINTER SWIMMING EXERCISE ON THE CARDIOVASCULAR SYSTEM IN THE MIDDLE‑AGED AND ELDERLY

Journal: Matrix Science Pharma (MSP)
Author: F. Wang, S. S. Li

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_3_19

ABSTRACT

Objectives: The aim of the study is to apply the fuzzy clustering algorithm to medical image segmentation technology and analyze the application effect of the algorithm. Methods: Thirty cases were included in the control group and seventy cases were in the winter swimming group. The control group and swimming group were 60–69 years of age in the elderly. The winter swimming group was followed for 1 year and the control group carried out an index test the same year. Four items of blood lipid, electrocardiogram, and cardiac function parameters were selected as index. Results: The high‑density lipoprotein cholesterol of the winter swimming group was significantly higher than that of the control group (P < 0.05), but there was no significant difference in low‑density lipoprotein cholesterol, total cholesterol, and triglyceride (P > 0.05); the comparison of serum cytokines were weak but in a positive direction. Conclusions: Long‑term insist to winter swimming can make the heart to adapt to the morphological changes, improve cardiac function, improve myocardial blood supply, improve blood lipid metabolism, and reduce the risk of Arsenic (AS).

Pages 12-15
Year 2019
Issue 1
Volume 3

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February 12, 2026 In Uncategorized

msp.01.2019.09.11

RESEARCH ON MEDICAL IMAGE SEGMENTATION BASED ON FUZZY CLUSTERING ALGORITHM

Journal: Matrix Science Pharma (MSP)
Author: J. Li, Y. Ning, Z. M. Yuan, C. J. Yang

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP..MTSP_3_19

ABSTRACT

Objectives: The aim of the study is to apply the fuzzy clustering algorithm to medical image segmentation technology and analyze the application effect of the algorithm. Methods: In this study, the application of bacterial fuzzy clustering algorithm and bacterial foraging optimization algorithm in tooth image segmentation is analyzed. Among them, bacteria fuzzy clustering algorithm is a research group, whereas bacteria foraging optimization algorithm is a conventional group. Relevant researchers need to compare the separation index, partition coefficient, and partition index of the two algorithms. Results: Compared with the conventional group, the separation index and the partition coefficient of the experimental group were relatively high, and the two groups in the separation index and partition coefficients have a statistically significant difference (P < 0.05); compared with the experimental group, the index value was higher in the conventional group, and there was significant difference between the two groups in the zoning index (P < 0.05). Conclusions: Compared with the traditional bacterial optimization algorithm, the application of the bacterial fuzzy clustering algorithm in tooth image segmentation is more remarkable.

Pages 09-11
Year 2019
Issue 1
Volume 3

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