Matrix Science Pharma (MSP)

Investigating the Effects of Dietary Supplementation of Eucalyptus camaldulensis Essential Oil on Hemato‑biochemical Indices, Immune Response, and Oxidative Stress of Weaned Rabbits

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February 20, 2026 In Uncategorized

msp.03.2023.103.108

INVESTIGATING THE EFFECTS OF DIETARY SUPPLEMENTATION OF EUCALYPTUS CAMALDULENSIS ESSENTIAL OIL ON HEMATO‑BIOCHEMICAL INDICES, IMMUNE RESPONSE, AND OXIDATIVE STRESS OF WEANED RABBITS

Journal: Matrix Science Pharma (MSP)
J. O. Alagbe

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/mtsp.mtsp_17_23

ABSTRACT

A variety of plants, including herbs, spices, and essential oils and oleoresins generated from plants, are used as phytogenic feed additives. Numerous biological functions are expressed by essential oils, including antibacterial, anti‑inflammatory, immunostimulatory, hepatoprotective, and antifungal ones. Numerous studies were done to investigate options after antimicrobial growth promoters were outlawed in the European Union and other nations in 2009. The use of antibiotics in
chickens must be reduced to lower the danger of antibiotic resistance globally

Pages 103-108
Year 2023
Issue 3
Volume 7

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February 20, 2026 In Uncategorized

msp.03.2023.95.102

DIGITAL TRANSFORMATION IN PHARMACEUTICAL SUPPLY CHAIN: AN AFRICAN CASE

Journal: Matrix Science Pharma (MSP)
Bankole Ibrahim Ashiwaju, Mercy Odochi Agho, Casandra Okogwu, Ochuko Felix Orikpete, Chibuike Daraojimba

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/mtsp.mtsp_16_23

ABSTRACT

The pharmaceutical supply chain serves as a crucial lifeline in the health‑care ecosystem, responsible for delivering life‑saving medicines from production facilities to the hands of patients. Its seamless operation ensures that health challenges, from chronic illnesses to sudden outbreaks, can be addressed timely and effectively.[1] In the vast and diverse continent of Africa, the importance of this chain is accentuated, given the range of health issues faced by its populace, including endemic diseases such as malaria, emerging health threats, and a rising tide of noncommunicable diseases

Pages 95-102
Year 2023
Issue 3
Volume 7

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February 20, 2026 In Uncategorized

msp.03.2023.85.94

ENVIRONMENTAL IMPACT OF PHARMACEUTICALS: A COMPREHENSIVE REVIEW

Journal: Matrix Science Pharma (MSP)
Bankole Ibrahim Ashiwaju, Chinedum Gloria Uzougbo, Ochuko Felix Orikpete

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/mtsp.mtsp_15_23

ABSTRACT

This comprehensive review seeks to evaluate and synthesize the extensive literature regarding the environmental impact of pharmaceuticals, a growing area of concern within the realm of environmental science. Pharmaceuticals, including human and veterinary medicines, have been detected ubiquitously in the environment due to their widespread use and incomplete removal during wastewater treatment processes. These
substances pose potential ecological risks due to their bioactive properties, but the magnitude and implications of these impacts are not yet fully understood. Our review covers the major aspects such as pathways of environmental entry, detection methods, potential impacts on flora and fauna, and potential human health implications of pharmaceutical contamination. We further explored the effectiveness of current wastewater treatment technologies in removing these substances and assess the potential of emerging technologies. The review concludes by discussing policy implications and the necessity for a global coordinated response. By encapsulating the breadth of research in this area, we hope to spur further research and foster greater awareness of the environmental implications of pharmaceutical waste.

Pages 85-94
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.03.2023.73.84

A STEP TOWARD SUSTAINABILITY: A REVIEW OF BIODEGRADABLE PACKAGING IN THE PHARMACEUTICAL INDUSTRY

Journal: Matrix Science Pharma (MSP)
Bankole Ibrahim Ashiwaju, Ochuko Felix Orikpete, Akeeb Adepoju Fawole, Elesho Yusuf Alade, Casandra Odogwu

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/mtsp.mtsp_22_23

ABSTRACT

In an era marked by a burgeoning environmental crisis, the pharmaceutical industry’s reliance on nonbiodegradable packaging has become a pressing concern. This comprehensive review marks a pioneering effort to examine the entire spectrum of pharmaceutical packaging, from traditional materials to innovative biodegradable alternatives, with an emphasis on the industry’s role in sustainability. Beginning with a detailed investigation into the prevalent materials and their environmental impact, the review unveils a landscape riddled with challenges but ripe with opportunities. By delving into biodegradable packaging technologies, including polylactic acid, polyhydroxyalkanoates, and other biopolymers, we present a cogent roadmap toward an eco‑friendly future. Our analysis further extends to the intricate web of regulations, market dynamics, consumer behavior, real‑world applications, and critical future directions. The study culminates in a robust set of recommendations that amalgamate scientific innovation with practical strategies, thus setting a precedent for collaborative action. This review stands as a seminal contribution to the field, offering a holistic perspective on an issue central to global sustainability and human well‑being. Its findings not only underline the feasibility of transitioning to sustainable packaging within the pharmaceutical industry but also underscore the urgency of this shift. The paper concludes with a resonant call to action, inviting all stakeholders to partake in a collective endeavor that transcends conventional boundaries and illuminates a path toward a greener, healthier world.

Pages 73-84
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.62.72

ECONOMIC AND MEDICINAL IMPORTANCE OF NONTIMBER FOREST PRODUCTS AT YONI CHIEFDOM, SIERRA LEONE

Journal: Matrix Science Pharma (MSP)
Otesile Adegboyega Ayodeji, Adeyinka Olufemi Adepoju, Turay Foday, Sheriff Kadijatu Bridget

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/mtsp.mtsp_12_23

ABSTRACT

Forest‑based nontimber product NTFPs are a broad categor of economic or subsistence items derived from forests but not including timber. They could also be thought of as broadly speaking biological resource‑derived products. Forest products other than wood NTFPs include a variety of plant and animal items that are gathered from forests, savannahs, and other types of natural vegetation. Canoes, wood carving, local house
construction, fencing supplies, and firewood are all mentioned in this description, but industrial lumber is not included.

Pages 62-72
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.52.61

THE REASON FOR VITAMIN–MINERAL SUPPLEMENT INTAKE AMONG SECONDARY SCHOOL ADOLESCENTS IN MALAYSIA AND ITS ASSOCIATION WITH NUTRITIONAL STATUS AND DIETARY PRACTICE

Journal: Matrix Science Pharma (MSP)
Azli Baharudin, Fatimah Othman, Syafinaz Mohd Sallehuddin, Suhaila Abd Ghafar, Khairul Hasnan Amali, Norazizah Ibrahim Wong, Ahmad Ali Zainuddin

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/2521-0815.388366

ABSTRACT

In recent decades, the usage and availability of dietary supplements were dramatically increased due to the increasing health awareness among the public, especially after the sudden outbreak of the COVID‑19 pandemic (Weerasena et al., 2021). According to Fortune Business Insights(2022), the global market size of dietary supplements was USD 71.81 billion (RM 318.66 billion) in 2021 and was expected to reach USD 128.64 billion (RM 570.84 billion) in 2028 at a compound annual growth rate (CAGR) of 8.68%. Interestingly, one‑third of the market was contributed by vitamin and mineral supplements(VMS) (USD 20.16 billion) (Research and Markets, 2023). Asimilar trend goes to Malaysia, the dietary supplement market size has grown annually by 3.0% (CAGR 2018–2020), with a total of around USD 544 million (RM 2.2 billion) in 2020, and was believed to continue growing in the coming years (Koe, 2021; MADSA, 2019).

Pages 52-61
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.43.51

PHYTOCHEMICAL SCREENING AND ANTI‑INFLAMMATORY, ANTIOXIDANT, AND ANTIMICROBIAL INVESTIGATIONS ON EXTRACTS OF IXORA JAVANICA

Journal: Matrix Science Pharma (MSP)
Avijit Chaterjee, Debarati Chaterjee, Manik Ghosh, Pankaj Dagur, Jashanpreet Kaur, Naresh Kumar Rangra, Suddhasattya Dey, Arijit Mondal, Alindam Ghosh, Padmacharan Behera

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_2_23

ABSTRACT

Medicinal plants are the oldest source of essential medicines useful for human diseases because of their significant therapeutic value. The medicinal plants possess an exceptionally huge place as crude material for critical use of medications. They enclose phytoconstituents, which are utilized in the cure of numerous human diseases. Plants are considered an abundant source of environmentally created optional metabolites, which are powerful solutions for various diseases. A critical problem in pharmacotherapeutics is emerging in the form of multiple drug resistance. However, medicinal plants are considered rich sources for antimicrobial agents.[1] Hence, phytochemical evaluation of diverse plant species for medicinal leads to gain much consideration.

Pages 43-51
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.36.42

THE INTERSECTION OF ARTIFICIAL INTELLIGENCE AND BIG DATA IN DRUG DISCOVERY: A REVIEW OF CURRENT TRENDS AND FUTURE IMPLICATIONS

Journal: Matrix Science Pharma (MSP)
Bankole Ibrahim Ashiwaju, Ochuko Felix Orikpete, Chinedum Gloria Uzougbo

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_14_23

ABSTRACT

The pharmaceutical landscape has been continually evolving, adapting to the myriad technological advancements of the 21st century. Among these innovations, artificial intelligence (AI) and big data have emerged as transformative tools, altering the trajectory of drug discovery processes. This review elucidates the symbiotic relationship between AI and big data in modern drug discovery, highlighting the profound enhancements in efficiency, precision, and innovation. Drawing from current research trends, we delve into the potent capabilities of AI‑powered algorithms to process, analyze, and glean insights from massive, multifaceted datasets. Furthermore, we explore the tangible impacts on drug repurposing, predictive modeling, molecular simulation, and clinical trials. Yet, this merger is not devoid of challenges. The review also critically examines inherent obstacles such as data integrity, the interpretability of AI models, and the evolving regulatory frameworks. As we gaze into the future of drug discovery, this intersection of AI and big data offers promising horizons, with implications not only for faster, more precise drug development but also for personalized, efficient patient care. This article aims to provide a comprehensive perspective on the current landscape while forecasting the transformative potential in the upcoming decades.

Pages 36-42
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.02.2023.27.35

AN EXPERIMENTAL STUDY: THE EFFECT OF GARCINIA KOLA ON SUPEROXIDE DISMUTASE, CATALASE, AND LIPID PEROXIDATION LEVELS IN THE KIDNEY OF MICE

Journal: Matrix Science Pharma (MSP)
Chinedum Gloria Uzougbo, Bankole Ibrahim Ashiwaju

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_13_23

ABSTRACT

Garcinia kola is a tropical plant with various traditional medicinal uses, and its potential effects on antioxidant enzymes and lipid peroxidation make it a subject of interest for scientific investigation. This study was conducted over 2 months and 6 days to investigate the effect of consuming G. kola on catalase and superoxide dismutase (SOD) activities and lipid peroxidation levels in the kidney of mice. Twelve female albino mice were divided into four groups, each consisting of three. Group 1 (control) received only growers mash, while groups A, B, and C were fed diets containing 1%, 3%, and 6% G. kola, respectively. The study revealed that mice fed with 1% G. kola exhibited a significant increase in SOD activity in their kidneys compared to other experimental groups. However, no significant changes were observed in catalase activity and lipid peroxidation levels among all the experimental groups. These findings suggest that dietary consumption of G. kola appears to be nontoxic to mice.

Pages 27-35
Year 2023
Issue 2
Volume 7

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February 20, 2026 In Uncategorized

msp.01.2023.22.26

PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF ZANTHOXYLUM ACANTHOPODIUM DC. ESSENTIAL OILS

Journal: Matrix Science Pharma (MSP)
Eldiza Puji Rahmi, Feda Anisah Makkiyah, Abdi Wira Septama, Aprilia Nur Tasfiyati, Rizna Triana Dewi

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

DOI: 10.4103/MTSP.MTSP_9_23

ABSTRACT

In recent years, it has become increasingly evident that herbal remedies can effectively cure inflammatory and oxidant‑related diseases. Oxidative stress contributes significantly to the development of age‑related and degenerative diseases, such as cancer, diabetes, cardiovascular disease, atherosclerosis, and neurodegenerative diseases. The body produces enzymatic and nonenzymatic antioxidant defenses, whereas other antioxidants are received through the diet. Together, these defenses transform free radicals into nonreactive forms. Among these, the potential antioxidant properties of plant essential oils have been explored. Plant essential oils contain these capacities, which can be related to the existence of terpenes and phenolic components that contribute to free radical scavenging action

Pages 22-26
Year 2023
Issue 1
Volume 7

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