Matrix Science Pharma (MSP)

The Ceftriaxone given by the systemic route of administration that utilized to administer antibiotic for prevention of postoperative infection. It ensures uniform antibiotic distribution in the body, therefore, to stop an infection from occurring, a stable dosage form that delivers medications to the infection site at an effective concentration is required. The present study aimed to develop a biodegradable lipid implant for site administration, evaluate various formulations, and examine the stability of an optimum formulation. The different formulations were developed by molding technique and studied for their physical properties, swelling ratio, friability, weight variation, content uniformity, dissolution, gel method, and stability of optimized formulation. This study indicated that all formulations were passed all the tests successfully, and the kinetic study after dissolution, and gel method of formulations were followed Korsmeyer and Peppas model. Among the all formulations Ceftriaxone1 was found to be the best formula because it passed all the tests successfully and had less flocculation in release profile. Accordingly, this formula subjected to stability studies. Based on the results obtained from stability studies, Ceftriaxone1 showed no significant difference of the drug content. From the value of similarity factor, it can be concluded that the release pattern ofCeftriaxone1 among period of stability studied are similar. In conclusion, lipid base biodegradable Ceftriaxone was prepared successfully, and they passed all the tests. The optimized formulations are stable after stability studies as per ICH guidelines.