The Ceftriaxone given by the systemic route of administration that utilized to administer antibiotic forprevention of postoperative infection. It ensures uniform antibiotic distribution in the body, therefore, to stopan infection from occurring, a stable dosage form that delivers medications to the infection site at an effectiveconcentration is required. The present study aimed to develop a biodegradable lipid implant for siteadministration, evaluate various formulations, and examine the stability of an optimum formulation. Thedifferent formulations were developed by molding technique and studied for their physical properties,swelling ratio, friability, weight variation, content uniformity, dissolution, gel method, and stability ofoptimized formulation. This study indicated that all formulations were passed all the tests successfully, andthe kinetic study after dissolution, and gel method of formulations were followed Korsmeyer and Peppasmodel. Among the all formulations Ceftriaxone1 was found to be the best formula because it passed all thetests successfully and had less flocculation in release profile. Accordingly, this formula subjected to stabilitystudies. Based on the results obtained from stability studies, Ceftriaxone1 showed no significant differenceof the drug content. From the value of similarity factor, it can be concluded that the release pattern ofCeftriaxone1 among period of stability studied are similar. In conclusion, lipid base biodegradableCeftriaxone was prepared successfully, and they passed all the tests. The optimized formulations are stableafter stability studies as per ICH guidelines.