Matrix Science Pharma (MSP)

ABSTRACT

The concept of medical reversal, introduced by Prasad refers to the phenomenon where new, methodologically robust, and conclusive evidence contradicts previously accepted practices. Medical reversal has tremendous implications in neurosurgical practice. Patients may undergo unnecessary interventions that lead to adverse effects, potentially harming their health and adversely impacting healthcare systems due to increased costs and resource utilization. Neurosurgeons must provide care based on evidence which is the most recent. One of the advantages of evidence‑based medicine (EBM) is the contribution of well‑conducted randomized controlled trials that feature improved blinding, better controls, greater statistical power, well‑defined endpoints, and reduced bias. Ioannidis[2] explained why most published research findings are false in six corollaries.