Matrix Science Pharma (MSP)

ABSTRACT

Demineralization of labyrinth and, in particular, otoconia dislodgment can result from low serum vitamin D levels. Vitamin D regulates expression of pro-inflammatory mediators and has a potent immunomodulatory effect. Increased inflammatory responses in inner ear have been linked to vitamin D deficiency. Patients with Meniere’s illness, sensorineural hearing loss (SNHL), and paroxysmal positional vertigo are frequently deficient in vitamin D. The commonest peripheral etiology of vertigo is benign paroxysmal positional vertigo (BPPV). One of the possible causes of BPPV development is a vitamin D deficiency. Low mineral density and vitamin D deficiency are also risk factors for vestibulocochlear diseases, including age-related hearing loss. Supplementation of vitamin D may improve the auditory recovery and vestibular disorders like BPPV. The recurrence of BPPV can be significantly reduced with vitamin D treatment alone. The present narrative review will consider the role of vitamin D in otological and neurotological disorders.