Ocimum suave aerial parts were acquired in Nigeria's Nassarawa State. Following that, the essential oil was extracted utilizing solvent extraction and hydro distillation techniques. The volatile constituents were identified by gas chromatography using the direct injection method. Staphylococcus aureus, Bacillus subtilis, streptococcus pneumoniae, pseudomonas aeruginosa, and E. coli were used to test certain volatile constituents for minimum bactericidal concentration (MBC) and minimum inhibition concentration (MIC). In Ocimum suave, forty-three compounds of terpenoids were identified with geranial (34.44, 36.16%), neral (32.67, 26.14%), β-caryophyllene (8.77, 10.15%), Linalool (6.54, and. 05%), allo-ocimene (4.23, 2.92%), Linalyl acetate (1.90, 4.85%), nerol (1.53, 2.06), geraniol (1.24, 1.35%) and β-bisabolene (1.17, 1.79%) respectively as the major constituents for hydro distillation and solvent extraction methods. The results of the extraction generally showed that hydro-distillation is better extraction method, and is also cheaper economically. The volatile constituents showed more some measure of activity against pathogens used.