Kalanchoe pinnata, also known as Bryophyllum pinnatum, is a succulent plant native to Madagascar that has been extensively utilized in traditional medicine for its curative effects. This study looks at the gastroprotective properties of an aqueous extract of Kalanchoe pinnata (AKP) against ethanol-induced stomach ulcers in Wistar rats. The plant's phytochemicals, including flavonoids, saponins, tannins, and alkaloids, are known for their antibacterial, anti-inflammatory, and wound-healing properties. Thirty Wistar rats were separated into six groups and given AKP, omeprazole, or no therapy after ethanol-induced stomach injury. Histological investigations revealed that the control group had normal gastric architecture, but the ethanol-only group suffered severe stomach injuries. Treatment with 0.5 ml AKP resulted in limited protection, while 1 ml AKP had strong gastroprotective effects comparable to omeprazole. The untreated group showed persistent severe damage. These findings support the historic usage of Kalanchoe pinnata to as treatment agent in traditional medicine while also highlighting its potential for modern therapeutic applications. The study recommends more investigation into the biochemical principles and clinical efficacy of Kalanchoe pinnata to fully grasp its therapeutic potential.